Jane was wasting away.

Young Fred Banting could only wait and hope as his closest friend, once a sunny, beautiful child, was taken captive by an untreatable nightmare. Her skin was withering to dry parchment. Her lips were rough, her thirst was perpetual, and soon her frail fourteen-year-old body was nothing more than a skeleton. It was not long before Jane slipped into an inescapable coma. Banting had to carry the coffin of his best friend,
 a victim of diabetes (Berger 58). 

Years later, Sir Frederick Banting's 
discovery of insulin was an innovative medical breakthrough that not only had an impact upon treatment for a once life-threatening disease, but also saved millions of lives, changed the world of medicine, and laid the foundation for the future of more effective diabetic treatment.