Hope at Last

“The extract at this time was sufficiently purified to be tested on three cases
 of diabetes mellitus in the wards of the Toronto General Hospital,” (Banting 4)

     Once the purification of insulin was sufficient for human use, Banting and Best published "The Internal Secretion of the Pancreas," in the Journal of Laboratory and Clinical Medicine (Lerner). The team now had scientists' attention worldwide.
[Click to enlarge]

First Success

     In January 1922, the first human to receive insulin was Leonard Thompson, a 14-year old boy dying of diabetes in Toronto (Candau 3). With the first injection, Thompson's blood sugar levels dropped dramatically. Soon, he was rapidly regaining strength and appetite. Thompson recovered and was discharged from the hospital in May 1922. With nothing to lose, many dying diabetics volunteered to be treated with insulin and had similar positive results ("The Discovery of Insulin").
Leonard Thompson (McCormick)

Miracle Drug

A published account of a diabetic woman's success with insulin:
“Her response to the insulin treatment was immediate. The injections of the extract which have been administered subcutaneously, generally once or twice a day since she has been here have provided the element in her blood which accomplished the necessary oxidation of sugar and she has accordingly been able to extend her diet until it is practically normal. There has been a consequent general improvement in her physique as indicated by the gain in weight and her bright, attractive personality is permitted to reassert itself.” (“Miss Hughes, Ill of Diabetes, Gains by Insulin ‘Cure’”)
Before and after receiving insulin (McCormick)